There are some video game related comics out there. My personal favorite (and I think most others) would have to be Penny Arcade. PA has been around for a few years and has built up quite a following. They even have started one of the biggest and best gaming expos in the country. And most recently, they have release an episodic game centered around the two main characters, Gabe and Tycho.

Almost always funny, sometimes crude, sometimes irreverent, but always good for a laugh. Check it out.

A few of my other favorite comics are:
2PStart
Ctrl Alt Del
Digital Unrest

Do you have a favorite web comic?